PUBLICATIONS

Scaling theory for the kinetics of mechanochemical reactions with convective flow

Yamamoto, T.*; Kubota, K.; Harabuchi, Y.; Ito, H. RSC Mechanochem. 2025, Just Accepted
DOI: 10.1039/D4MR00091A

Mechanochemical Generation of Aryl Barium Nucleophiles from Unactivated Barium Metal

Kubota, K.*; Kawamura, S.; Jiang, J.; Maeda, S.; Ito, H.* Chem. Sci. 2024, Just Accepted
DOI: 10.1039/D4SC05361C

Direct arylation of alkyl fluorides using in situ mechanochemically generated calcium-based heavy Grignard reagents

Gao, P.; Jiang, J.; Fukuzawa, Y.; Maeda, S.; Kubota, K.*; Ito, H.* RSC Mechanochem. 2024, 1, 486–491.
DOI: 10.1039/D4MR00067F

Solid-state Dynamics of Binuclear N-Heterocyclic Carbene Au(I) Rotor with para-Phenylene Rotator

Jiang, P.; Mikherdov, A. S.; Ito, H.*; Jin, M.* Chem. Lett. 2024, upae139.
DOI: doi.org/10.1093/chemle/upae139

Dissolution-Limited Reactions in Solid-State Synthesis

Yamamoto, T.*; Kubota, K.; Ito, H. J. Soc. Rheol. Jpn. 2024, 52, 161–170.
DOI: 10.1678/rheology.52.161

Crystallization-Induced Chirality Transfer in Conformationally Flexible Azahelicene Au(I) Complexes with Circularly Polarized Luminescence Activation

Jiang, P.; Mikherdov, A. S. ; Ito, H.*; Jin, M.* J. Am. Chem. Soc. 2024, 146, 12463–12472.
DOI: 10.1021/jacs.4c00345

Mechanochemistry Enabled Highly Efficient Solvent-Free Deoxygenation of Phosphine Oxides in Air

Kubota, K.*; Hisazumi, R.; Seo, T.; Ito, H.* RSC Mechanochem. 2024, 1, 250–254.
DOI: 10.1039/D4MR00011K

Highly Efficient and Air-tolerant Calcium-based Birch Reduction Using Mechanochemistry

Kubota, K.*; Fukuzawa, Y.; Kondo, K.; Gao, Y.; Ito, H.* Chem. Lett. 2024, 53, upae060.
DOI: 10.1093/chemle/upae060

Solid-state nickel(0)-mediated Yamamoto coupling enabled by mechanochemistry

Kubota, K.*; Shizukuishi, N.; Kubo, S.; Ito, H.* Chem. Lett. 2024, 53, upae056.
DOI: 10.1093/chemle/upae056

Mechanochemistry enabling highly efficient Birch reduction using sodium lumps and D-(+)-glucose

Kondo, K.; Kubota, K.*; Ito, H.* Chem. Sci. 2024, 15, 4452–4457.
DOI: 10.1039/D3SC06052G

Solid-State Mechanochemistry for the Rapid and Efficient Synthesis of Tris-Cyclometalated Iridium(III) Complexes

Kubota, K.*; Endo, T.; Ito, H.* Chem. Sci. 2024, 15, 3365–3371.
DOI: 10.1039/D3SC05796H

Ring Expansion of Cyclic Boronates via Oxyboration of Arynes

Shiratori, Y. ; Jiang, J.; Kubota, K.; Maeda, S; Ito, H.* J. Am. Chem. Soc. 2024, 146, 1765.
DOI: 10.1021/jacs.3c11851

Using Mechanochemistry to Activate Commodity Plastics as Initiators for Radical Chain Reactions of Small Organic Molecules

Kubota, K.*; Jiang, J.; Kamakura, Y.; Hisazumi, R.; Endo, T.; Miura, D.; Kubo, S.; Maeda, S.; Ito, H.* J. Am. Chem. Soc. 2024, 146, 1062.
DOI: 10.1021/jacs.3c12049

A Steric-Repulsion-Driven Clutch Stack of Triaryltriazines: Correlated Molecular Rotations and a Thermo-Responsive Gear-shift in the Crystalline Solid

Jin, M.*; Kitsu, R.; Hammyo, N.; Sato-Tomita, A.; Mizuno, M.; Mikherdov, A. S.; Tsitsvero, M.; Lyalin, A.; Taketsugu, T.; Ito, H.* J. Am. Chem. Soc. 2023, 145, 27512.
DOI: 10.1021/jacs.3c08909

Mechanochemical Synthesis of Non-Solvated Dialkylalumanyl Anion and XPS Characterization of Al(I) and Al(II) Species

Kurumada, S.; Yamanashi, R.; Sugita, K.; Kubota, K.; Ito, H.; Ikemoto, S.; Chen, C.; Moriyama, T.; Muratsugu, S.; Tada, M.; Koitaya, T.; Ozaki, T.; Yamashita, M.* Chem. Eur. J. 2023, e202303073.
DOI: 10.1002/chem.202303073

Solid-state mechanochemical cross-coupling of insoluble substrates into insoluble products by removable solubilizing silyl groups: Uniform synthesis of nonsubstituted linear oligothiophenes

Kubota, K.*; Kondo, K.; Seo, T.; Jin, M.; Ito, H.* RSC Adv. 2023, 13, 28652–28657.
DOI: 10.1039/D3RA05571J

Stereospecific synthesis of silicon-stereogenic optically active silylboranes and general synthesis of chiral silyl anions

Wang, X.; Feng, C.; Jiang, J.; Maeda, S.; Kubota, K.*; Ito, H.* Nature Commun. 2023, 14, 5561.
DOI: 10.1038/s41467-023-41113-z

Giant Crystalline Molecular Rotors that Operate in the Solid State

Ando, R.; Sato-Tomita, A.; Ito, H.*; Jin, M.* Angew. Chem. Int. Ed. 2023, 135, e202309694.
DOI: 10.1002/ange.202309694

Dual Nickel(II)/Mechanoredox Catalysis: Mechanical-force-driven Aryl-amination Reactions Using Ball Milling and Piezoelectric Materials

Seo, T.; Kubota, K.*; Ito, H.* Angew. Chem. Int. Ed. 2023, 62, e202311531.
DOI: 10.1002/anie.202311531

Synthesis of (Z)-alkenyl boronates via a copper(I)-catalyzed linear-selective alkylboration of terminal allenes

Ozawa, Y.; Shiratori, Y.; Koriyama, H.; Endo, K.; Iwamoto, H.; Ito, H.* Org. Chem. Front. 2023, 10, 4786–4793.
DOI: 10.1039/D3QO01095C

Synthesis of Fluoromethyl-substituted Cyclopropanes by Electrophilic Cyclization of Homoallylic Boronate Intermediates

Oyama, N.; Ito, H.* Adv. Synth. Catal. 2023, 365, 3241–3246.
DOI: 10.1002/adsc.202300529

Iterative Synthesis of Oligosilanes Using Methoxyphenyl- or Hydrogen-Substituted Silylboronates as Building Blocks: A General Synthetic Method for Complex Oligosilanes

Takeuchi, T.; Roy, A.; Ito, H.* J. Am. Chem. Soc. 2023, 145, 16249–16260.
DOI: doi.org/10.1021/jacs.3c05385

Construction of a Helical Structure with a Parallel Alignment of Molecular Dipoles in Crystals by Utilizing a Halogen-3 Synthon and a Bulky Silyl Spacer

Hammyo, N.; Jin, M.*; Ito, H.* Cryst. Growth Des. 2023, 23, 4514–4521.
DOI: 10.1021/acs.cgd.3c00282

Exploring Au(I) Involving Halogen Bonding with N-Heterocyclic Carbene Au(I) Aryl Complexes in Crystalline Media

Mikherdov, A. S.; Jin, M.*; Ito, H.* Chem. Sci. 2023, 14, 4485–4494.
DOI: 10.1039/D3SC00373F

An Improved Catalytic System for Solid-state Iridium(I)-catalyzed C–H Borylation Using Mechanochemistry

Kondo, K.; Kubota, K.*; Ito, H.* Chem. Lett. 2023, 52, 333–336.
DOI: 10.1246/cl.230081

Mechanochemical Approach for Air-Tolerant and Extremely Fast Lithium-Based Birch Reductions in Minutes

Gao, Y.; Kubota, K.*; Ito, H.* Angew. Chem. Int. Ed. 2023, 62, e202217723.
DOI: 10.1002/anie.202217723

In Situ and Real-Time Visualization of Mechanochemical Damage in Double-Network Hydrogels by Prefluorescent Probe via Oxygen-Relayed Radical Trapping

Zheng, Y.; Jiang, J.; Jin, M.*; Miura, D.; Lu, F. X.; Kubota, K.; Nakajima, T.; Maeda, S.*; Ito, H.*; Gong, J. P.* J. Am. Chem. Soc. 2023, 145, 7376–7389.
DOI: 10.1021/jacs.2c13764

Mechanochemistry-Directed Ligand Design: Development of a High-Performance Phosphine Ligand for Palladium-Catalyzed Mechanochemical Organoboron Cross-Coupling

Seo, T.; Kubota, K.*; Ito, H.* J. Am. Chem. Soc. 2023, 145, 6823–6837.
DOI: 10.1021/jacs.2c13543

Multidynamic Crystalline Molecular Rotors Comprising an N-Heterocyclic Carbene Binuclear Au(I) Complex Bearing Multiple Rotators

Jin, M.*; Matsuura, S.; Yamamoto, H.; Mizuno, M.; Ito, H.* Eur. J. Org. Chem. 2023, 26, e202201468.
DOI: 10.1002/ejoc.202201468

Solid-state Silver-catalyzed Ring-opening Fluorination of Cyclobutanols Using Mechanochemistry

Isshiki, R.*; Kubota, K.*; Ito, H.* Synlett 2023, 34, 1419–1424.
DOI: 10.1055/a-2021-9599

Copper(I)-Catalyzed Regio- and Stereoselective Silaboration of Terminal Allenes

Ozawa, Y.; Koriyama, H.; Shiratori, Y.; Ito, H.* ACS Org. Inorg. Au 2023, 3, 104–108.
DOI: 10.1021/acsorginorgau.2c00057

Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions

Kubota, K.*; Seo, T.; Ito, H.* Faraday Discuss. 2023, 241, 104–113.
DOI: 10.1039/D2FD00121G

Mechanochemical Protocol Facilitates the Generation of Arylmanganese Nucleophiles from Unactivated Manganese Metal

Takahashi, R.; Gao, P.; Kubota, K.*; Ito, H.* Chem. Sci. 2023, 14, 499–505.
DOI: 10.1039/D2SC05468J

Mechanical deformation and multiple thermal restoration of organic crystals: reversible multi-stage shape-changing effect with luminescence-color changes

Feng, C.; Seki, T.*; Sakamoto, S.; Sasaki, T.; Takamizawa, S.*; Ito, H.* Chem. Sci. 2022, 13, 9544–9551.
DOI: 10.1039/D2SC03414J

Cu(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl- and Silyl-substituted Alkenes

Oyama, N.; Akiyama, S.; Kubota, K.; Imamoto, T.; Ito, H.* Eur. J. Org. Chem. 2022, e202200664.
DOI: 10.1002/ejoc.202200664

Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon−Carbon Bond-Forming Reactions

Gao, P.; Jiang, J.; Maeda, S.; Kubota, K.*; Ito, H.* Angew. Chem. Int. Ed. 2022, 61, e202207118.
DOI: 10.1002/anie.202207118

Palladium-catalyzed solid-state borylation of aryl halides using mechanochemistry

Kubota, K.*; Baba, E.; Seo, T.; Ishiyama, T.; Ito, H.* Beilstein J. Org. Chem. 2022, 18, 855.
DOI: 10.3762/bjoc.18.86

Conformationally Fixed Chiral Bisphosphine Ligands by Steric Modulators on the Ligand Backbone: Selective Synthesis of Strained 1,2-Disubstituted Chiral cis-Cyclopropanes

Iwamoto, H.; Ozawa, Y.; Hayashi, Y.; Imamoto, T.; Ito, H.* J. Am. Chem. Soc. 2022, 144, 10483–10494.
DOI: 10.1021/jacs.2c02745

Insight into the Reactivity Profile of Solid-State Aryl Bromides in Suzuki-Miyaura Cross-Coupling Reactions Using Ball Milling

Kubota, K.*; Kondo, K.; Seo, T.; Ito, H.* Synlett 2022, 33, 898–902.
DOI: 10.1055/a-1748-3797

Distinct Fold-Mode Formation of Crystalline Cu(I) Helical Coordination Polymers with Alternation of the Solid-State Emission Using Shape of the Counter Anions

Jin, M.*; Ando, R.; Ito, H.* Inorg. Chem. 2022, 61, 3–9.
DOI: https://doi.org/10.1021/acs.inorgchem.1c02725

Efficient Access to Materials-Oriented Aromatic Alkynes via the Mechanochemical Sonogashira Coupling of Solid Aryl Halides with Large Polycyclic Conjugated Systems

Gao, Y.; Feng, C.; Seo, T.; Kubota, K.*; Ito, H.* Chem. Sci. 2022, 13, 430–438.
DOI: 10.1039/D1SC05257H

Solid-State C−N Cross-Coupling Reactions with Carbazoles as Nitrogen Nucleophiles Using Mechanochemistry

Kubota, K.*; Endo, T.; Uesugi, M.; Hayashi, Y.; Ito, H.* ChemSusChem 2022, 15, e202102132.
DOI: 10.1002/cssc.202102132

Development of Selective Reactions Using Ball Milling

Kubota, K.*; Ito, H.* J. Synth. Org. Chem. Jpn. 2021, 79, 492–502.
DOI: 10.5059/yukigoseikyokaishi.79.492

Palladium-Catalyzed Solid-State Polyfluoroarylation of Aryl Halides Using Mechanochemistry

Takahashi, Rikuro; Seo, T.; Kubota, K.*; Ito, H.* ACS Catal. 2021, 11, 14803–14810.
DOI: 10.1021/acscatal.1c03731

Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis

Takahashi, R.; Hu, A.; Gao, P.; Gao, Y.; Pang, Y.; Seo, T.; Maeda, S.; Jiang, J.; Takaya, H.; Kubota, K.*; Ito, H.* Nature Commun. 2021, 12, 6691.
DOI: 10.1038/s41467-021-26962-w

Single Crystal Growth of π-Conjugated Large Molecules without Solubilizing Alkyl Chains via Naphthalene Flux Method

Yanase, T.; Tanoguchi, H.; Sakai, N.; Jin, M.; Yamane, I.; Kato, M.; Ito, H.; Nagahama, T.; Shimada, T. Cryst. Growth. Des. 2021, 21, 4683–4689.
DOI: https://doi.org/10.1021/acs.cgd.1c00538

Regio- and Stereoselective Synthesis of Multi-Alkylated Allylic Boronates through Three-Component Coupling Reactions between Allenes, Alkyl Halides, and a Diboron Reagent

Ozawa, Y.; Endo, K.; Ito, H.* J. Am. Chem. Soc. 2021, 143, 13865–13877.
DOI: https://doi.org/10.1021/jacs.1c06538

Synthesis of Hydrosilylboronates via the Monoborylation of a Dihydrosilane Si−H Bond and Their Application for the Generation of Dialkylhydrosilyl Anions

Takeuchi, T.; Shishido, R.; Kubota, K.*; Ito, H.* Chem. Sci. 2021, 12, 11799–11804.
DOI: 10.1039/D1SC01440D

Charge-Transfer Crystal with Segregated Packing Structure Constructed with Hexaarylbenzene and Tetracyanoquinodimethane

Ando, R.; Jin, M.*; Ito, H.* CrystEngComm 2021, 23, 5564–5568.
DOI: 10.1039/D1CE00726B

Synthesis of Chiral α-Amino Tertiary Boronates via the Catalytic Enantioselective Nucleophilic Borylation of Dialkyl Ketimines

Kubota, K.*; Miura, D.; Takeuchi, T.; Osaki, S.; Ito, H.* ACS Catal. 2021, 11, 6733–6740.
DOI: 10.1021/acscatal.1c01689

Introduction of a Luminophore into Generic Polymers via Mechanoradical Coupling with a Prefluorescent Reagent

Kubota, K.*; Toyoshima, N.; Miura, D.; Jiang, J.; Maeda, S.; Jin, M.*; Ito, H.* Angew. Chem. Int. Ed. 2021, 60, 16003–16008.
DOI: 10.1002/anie.202105381

Backbone-Modified C2-Symmetrical Chiral Bisphosphine TMS-QuinoxP*: Asymmetric Borylation of Racemic Allyl Electrophiles

Iwamoto, H.; Ozawa, Y.; Takenouchi, Y.; Imamoto, T.; Ito, H.* J. Am. Chem. Soc. 2021, 143, 6413–6422.
DOI: 10.1021/jacs.0c08899

(9-Isocyanoanthracene)gold(I) Complexes Exhibiting Two Modes of Crystal Jumps by Different Structure Change Mechanisms

Kato, K.; Seki, T.*; Ito, H.* Inorg. Chem. 2021, 60, 10849–10856. Just Accepted
DOI: 10.1021/acs.inorgchem.1c00881

Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides

Seo, T.; Toyoshima, N; Kubota, K.*; Ito, H.* J. Am. Chem. Soc. 2021, 143, 6165–6175.
DOI: 10.1021/jacs.1c00906

A Copper(I)-Catalyzed Radical Relay Reaction Enabling the Intermolecular 1,2-Alkylborylation of Unactivated Olefins

Akiyama, S.; Oyama, N.; Endo, T.; Kubota, K.; Ito, H.* J. Am. Chem. Soc. 2021, 143, 5260–5268.
DOI: 10.1021/jacs.1c02050

Synthesis and Optical Properties of C,N-Swapped Boranils Derived from Potassium Acyltrifluoroborates

Matsuura, S.; Taguchi, J.; Seki, T.; Ito, H.* Bull. Chem. Soc. Jpn. 2021, 94, 1547–1552.
DOI: 10.1246/bcsj.20210024

Encapsulating N-Heterocyclic Carbene Binuclear Transition-Metal Complexes as a New Platform for Molecular Rotation in Crystalline Solid-State

Jin, M.*; Ando, R.; Jellen, M. J.; Garcia-Garibay, M. A.; Ito, H.* J. Am. Chem. Soc. 2021, 143, 1144–1153.
DOI: https://doi.org/10.1021/jacs.0c11981

Copper(I)-Catalyzed Stereoselective Silylative Dearomatization of Indoles and Pyrroles using Silylboronates

Hayama, K.; Takahashi, Rikuro.; Kubota, K.; Ito, H.* Chem. Lett. 2021, 50, 289–292.
DOI: 10.1246/cl.200725

A Glove-box- and Schlenk-line-free Protocol for Solid-state C-N Cross-coupling Reactions Using Mechanochemistry

Kubota, K.*; Takahashi, Rikuro; Uesugi, M.; Ito, H.* ACS Sustainable Chem. Eng. 2020, 8, 16577–16582.
DOI: 10.1021/acssuschemeng.0c05834

Solid-State Radical C−H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials

Pang, Y.; Lee, J. W.; Kubota, K.*; Ito, H.* Angew. Chem. Int. Ed. 2020, 59, 22570–22576.
DOI: 10.1002/anie.202009844

General Synthesis of Trialkyl- and Dialkylarylsilylboranes: Versatile Silicon Nucleophiles in Organic Synthesis

Shishido, R.; Uesugi, M.; Takahashi, Rikuro.; Mita, T.; Ishiyama, T.; Kubota, K.*; Ito, H.* J. Am. Chem. Soc. 2020, 142, 14125–14133.
DOI: 10.1021/jacs.0c03011

Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by In-situ Crystallization

Seo, T.; Kubota, K.*; Ito, H.* J. Am. Chem. Soc. 2020, 142, 9884–9889.
DOI: 10.1021/jacs.0c01739

Photoluminescent Ferroelastic Molecular Crystals

Seki, T.*; Feng, C.; Kashiyama, K.; Sakamoto, S.; Takasaki, Y.; Sasaki, T.; Takamizawa, S.*; Ito, H.* Angew. Chem., Int. Ed. 2020, 59, 8839–8843.
DOI: 10.1002/anie.201914610

Copper(I)-Catalyzed Boryl Substitution of 1-Trifluoromethyl Allenes for the Synthesis of 3-Boryl-Substituted 1,1-gem-Difluorodienes

Akiyama, S.; Nomura, S; Kubota, K.; Ito, H.* J. Org. Chem. 2020, 85, 4172–4181.
DOI: 10.1021/acs.joc.9b03353

Mixed crystal formation of two gold isocyanide complexes with various ratios for continuous tuning of photophysical properties

Seki, T.*; Toyoshima, N.; Ito, H.* Dalton Trans. 2020, 49, 2073–2076.
DOI: 10.1039/D0DT00195C

Silyl-group-directed Linear-selective Allylation of Carbonyl Compounds with Trisubstituted Allylboronates Using a Copper(I) Catalyst

Iwamoto, H.; Hayashi, Y.; Ozawa, Y.; Ito, H.* ACS Catal. 2020, 10, 2471–2476.
DOI: 10.1021/acscatal.9b05408

Synthesis of Chiral N-Heterocyclic Allylboronates via the Enantioselective Borylative Dearomatization of Pyrroles

Hayama, K.; Kojima, R.; Kubota, K.; Ito, H.* Org. Lett. 2020, 22, 739–744.
DOI: 10.1021/acs.orglett.9b04581

Synthesis and Tunable Optical Properties of C,N-Chelated Borate Luminophores Derived from Potassium Acyltrifluoroborates

Taguchi, J.; Matsuura, S.; Seki, T.; Ito, H.* Chem. Eur. J. 2020, 26, 2450–2455.
DOI: 10.1002/chem.201904983

Crystal Jumping of Simple Hydrocarbons: Cooling-Induced Salient Effect of Bis-, Tri-, and Tetraphenylethene through Anisotropic Lattice Dimension Changes without Thermal Phase Transitions

Seki, T.*; Mashimo, T.; Ito, H.* Chem. Lett. 2020, 49, 174–177.
DOI: 10.1246/cl.190768

Aurophilicity-mediated Construction of Emissive Porous Molecular Crystals as Versatile Hosts for Liquid and Solid Guests

Seki, T.*; Ida, K.; Sato, H.; Aono, S.; Sakaki, S.; Ito, H.* Chem. Eur. J. 2020, 26, 735–744.
DOI: 10.1002/chem.201904597

Air- and moisture-stable Xantphos-ligated palladium dialkyl complex as a precatalyst for cross-coupling reactions

Takahashi, R.; Kubota, K.*; Ito, H.* Chem. Commun. 2020, 56, 407–410.
DOI: 10.1039/C9CC06946A

Mechanochemical cross-coupling reactions

Kubota, K.*; Ito, H.* Trends Chem. 2020, 2, 1066–1081.
DOI: 10.1016/j.trechm.2020.09.006

Redox Reactions of Small Organic Molecules Using Ball Milling and Piezoelectric Materials

Kubota, K.*; Pang, Y.; Miura, A.; Ito, H.* Science 2019, 366, 1500–1504.
DOI: 10.1126/science.aay8224

Anisotropic Thermal Expansion as the Source of Macroscopic and Molecular Scale Motion in Phosphorescent Amphidynamic Crystals

Jin, M.; Yamamoto, S.; Seki, T.; Ito, H.*; Garcia-Garibay, M. A.* Angew. Chem. Int. Ed. 2019, 58, 18003–18010.
DOI: 10.1002/anie.201909048

The Direct Dimesitylborylation of Benzofuran Derivatives via an Iridium-Catalyzed C–H Activation with Silyldimesitylborane

Shishido, R.; Sasaki, I.; Seki, T.; Ishiyama, T.; Ito, H.* Chem. Eur. J. 2019, 25, 12924–12928.
DOI: 10.1002/chem.201903776

Solid-State Suzuki-Miyaura Cross-Coupling Reactions: Olefin-Accelerated C–C Coupling Using Mechanochemistry

Seo, T.; Ishiyama, T.; Kubota, K.*; Ito, H.* Chem. Sci. 2019, 10, 8202–8210.
DOI: 10.1039/C9SC02185J

Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives

Akiyama, S.; Kubota, K.; Mikus, M. S.; Paioti, P. H. S.; Romiti, F.; Liu, Q.; Zhou, Y.; Hoveyda, A. H.*; Ito, H.* Angew. Chem. Int. Ed. 2019, 58, 11998–12003.
DOI: 10.1002/anie.201906283

Copper(I)-Catalyzed Enantioconvergent Borylation of Racemic Benzyl Chlorides Enabled by Quadrant-by-Quadrant Structure Modulation of Chiral Bisphosphine Ligands

Iwamoto, H.; Endo, K.; Ozawa, Y.; Watanabe, Y.; Kubota, K.; Imamoto, T.; Ito, H.* Angew. Chem. Int. Ed. 2019, 58, 11112–11117.
DOI: 10.1002/anie.201906011

Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(I)-catalysed borylative cyclization of aliphatic ketones

Kubota, K.; Uesugi, M.; Osaki, S.; Ito, H.* Org. Biomol. Chem. 2019, 17, 5680–5683.
DOI: 10.1039/C9OB00962K

Mechanochemistry allows carrying out sensitive organometallic reactions in air: Glove-box-and-Schlenk-line-free synthesis of oxidative addition complexes from aryl halides and palladium(0)

Kubota, K.*; Takahashi, R.; Ito, H.* Chem. Sci. 2019, 10, 5837–5842.
DOI: 10.1039/C9SC01711A

Luminescent mechanochromism of gold N-heterocyclic carbene complexes with hypso- and bathochromic spectral shifts

Seki, T.*; Kashiyama, K.; Ito, H.* Dalton Trans. 2019, 48, 7105–7109.
DOI: 10.1039/C9DT00566H

Concise Synthesis of Potassium Acyltrifluoroborates from Aldehydes by a Cu(I)-catalyzed Borylation/Oxidation Protocol

Taguchi, J.; Takeuchi, T.; Takahashi, R.; Masero, F.; Ito, H.* Angew. Chem. Int. Ed. 2019, 58, 7299–7303.
DOI: 10.1002/anie.201901748

Anisotropic strain release in a thermosalient crystal: Correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion

Seki, T.*; Mashimo, T.; Ito, H.* Chem. Sci. 2019, 10, 4185–4191.
DOI: 10.1039/C8SC05563G

Dependence of Absorption and Emission Spectra on Polymorphs of Gold(I) Isocyanide Complexes: Theoretical Study with QM/MM Approach

Aono, S; Seki, T.; Ito, H.; Sakaki, S.* J. Phys. Chem. C 2019, 123, 4773–4794.
DOI: 10.1021/acs.jpcc.8b10602

Iridium(I)-Catalyzed C-H Borylation in Air by Using Mechanochemistry

Pang, Y.; Ishiyama, T.; Kubota, K.*; Ito, H.* Chem. Eur. J. 2019, 25, 4654–4659.
DOI: 10.1002/chem.201900685

Olefin-accelerated solid-state C–N cross-coupling reactions using mechanochemistry

Kubota, K.*; Seo, T.; Koide, K.; Hasegawa, Y.; Ito, H.* Nature Communications 2019, 10, 111.
DOI: 10.1038/s41467-018-08017-9

Soft Crystal Force Field for Reproducing the Crystal Structures of Aryl Gold Isocyanide Complexes

Nakayama, N.; Obata, S.; Hori, Y.; Goto, H.*; Seki, T.; Ito, H. J. Comput. Chem. Jpn. 2018, 17, 155–157.
DOI: 10.2477/jccj.2018-0031

A Gold Isocyanide Complex with a Pendant Carboxy Group: Orthogonal Molecular Arrangements and Hypsochromically Shifted Luminescent Mechanochromism

Seki, T.*; Kobayashi, K.; Mashimo, T.; Ito, H.* Chem. Commun. 2018, 54, 13160–13160.
DOI: 10.1039/C8CC06490C

Copper(I)-Catalysed Stereoselective Debromoborylation of Aliphatic 1,1-Dibromo-1-Alkenes with Bis(pinacolato)diboron

Pang, Y.; Kojima, R.; Ito, H.* Org. Biomol. Chem. 2018, 16, 6187–6190.
DOI: 10.1039/C8OB01778F

Copper(I)-Catalyzed Stereoselective Defluoroborylation of Aliphatic Gem-Difluoroalkenes

Ito, H.*; Seo, T.; Kojima, R.; Kubota, K. Chem. Lett. 2018, 47, 1330–1332.
DOI: 10.1246/cl.180656

Computational design of high-performance ligand for enantioselective Markovnikov hydroboration of aliphatic terminal alkenes

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A Copper(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl-substituted Alkenes: Synthesis of Enantioenriched γ,γ-gem-Difluoroallylboronates

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Copper(I)-catalysed regio- and diastereoselective intramolecular alkylboration of terminal allenes via allylcopper(I) isomerization

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Copper(I)-Catalyzed Diastereoselective Dearomative Carboborylation of Indoles

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Copper(I)-Catalyzed Regio- and Stereoselective Intramolecular Alkylboration of Propargyl Ethers and Amines

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Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate

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Stereodivergent Hydrodefluorination of gem-Difluoroalkenes: Selective Synthesis of (Z)- and (E)-Monofluoroalkenes

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Tris(trimethylsilyl)silyl Boronate Esters: Novel Bulky, Air- and Moisture-Stable Silylboronate Ester Reagents for Boryl Substitution and Silaboration Reactions

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Formal Nucleophilic Silyl Substitution of Aryl Halides with Silyllithium Reagents via Halogenophilic Attack of Silyl Nucleophiles

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Tuning the Lifetime of Transient Phases of Mechanochromic Gold Isocyanide Complexes through Functionalization of the Terminal Moieties of Flexible Side Chains

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Triboluminescence of Lanthanide Coordination Polymers with Face-to-Face Arranged Substituents

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Mechano-Responsive Luminescence via Crystal-to-Crystal Phase Transitions between Chiral and Non-Chiral Space Groups

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Low-Temperature-Selective Luminescent Mechanochromism of a Thienyl Gold Isocyanide Complex

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Luminescent Mechanochromic 9-Anthryl Gold(I) Isocyanide Complex with an Emission Maximum at 900 nm after Mechanical Stimulation

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Copper(I)-Catalyzed Stereo- and Chemoselective Borylative Radical Cyclization of Alkyl Halides Bearing an Alkene Moiety

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Copper(I)-Catalyzed Enantioselective Nucleophilic Borylation of Ketones: Synthesis of Enantioenriched Chiral Tertiary alpha-Hydroxyboronates

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Copper(I)-Catalyzed Boryl Substitution of Allyl Aminals: Selective Synthesis of Linear γ-Aminoallylboronates

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Transition-Metal-Free Boryl Substitution using Silylboranes and Alkoxy Bases

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Formal Nucleophilic Borylation and Borylative Cyclization of Organic Halides

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Critical Role of Energy Transfer Between Terbium Ions for Suppression of Back Energy Transfer in Nonanuclear Terbium Clusters

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Copper(I)-Catalyzed Enantioselective Boryl Substitution of Allyl Acylals: An Efficient Approach for Enantioenriched α-Chiral γ-Acetoxyallylboronates

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Introduction of a Biphenyl Moiety for a Solvent Responsive Aryl Gold(I) Isocyanide Complex with Mechanical Reactivation

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Luminescent Europium(III) Coordination Zippers Linked with Thiophene-Based Bridges

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Direct Introduction of a Dimesitylboryl Group Using Base-Mediated Substitution of Aryl Halides with Silyldimesitylborane

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Synthesis of Enantiomerically Enriched Chiral Tetrahydroquinolines via Sequential Dearomatization/Enantioselective Borylation Reactions

Kubota, K.; Watanabe, Y.; Ito, H.* Adv. Synth. Catal. 2016, 358, 15, 2379–2384.
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Luminescent mechanochromism of a chiral complex: Distinct crystal structure and color changes of racemic and homochiral gold(I) isocyanide complexes with a binaphthyl moiety

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Hyper-stable organo-EuIII luminophore under high temperature for photo-industrial application

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A Screening Approach for the Discovery of Mechanochromic Gold(I) Isocyanide Complexes with Crystal-to-Crystal Phase Transitions

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Computational Insight into the Enantioselective Nucleophilic Borylation of a Polarized C=O Double Bond Catalyzed by Di-phosphine-Borylcopper(I) Complexes

Kubota, K.; Jin, M.; Ito, H.* Organometallics 2016, 35, 1376–1383.
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Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines

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Highly Selective Markovnikov Hydroboration of Alkyl-Substituted Terminal Alkenes with a Phosphine-Copper(I) Catalyst

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Mechanical Path to a Photogenerated Structure: Ball Milling-Induced Phase Transition of a Gold(I) Complex

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Regioselective C–H Borylation of Heteroaromatic Aldimines with Iridium Complexes

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Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single

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Mechanochromic Luminescence Based on Crystal-to-Crystal Transformation Mediated by a Transient Amorphous

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Effective Photosensitized Energy Transfer of Nonanuclear Terbium Clusters Using Methyl Salicylate Derivatives

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Seven-Coordinate Luminophores: Brilliant Luminescence of Lanthanide Complexes with C3v Geometrical Structures

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Enhanced Electric Dipole Transition in Lanthanide Complex with Organometallic Ruthenocene Units

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Luminescent Coordination Glass: Remarkable Morphological Strategy for Assembled Eu(III) Complexes

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Copper(I)-Catalyzed Diastereoselective Borylative Exo-Cyclization of Alkenyl Aryl Ketones

Yamamoto, E.; Kojima, R.; Kubota, K.; Ito, H. Synlett 2015, 27, 2, 272–276.
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Mismatched changes of the photoluminescence and crystalline structure of a mechanochromic gold(I) isocyanide complex

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Catalyst-Controlled Regiodivergent C-H Borylation of Multifunctionalized Heteroarenes by Using Iridium Complexes

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Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis

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Copper(I)-Catalyzed Carbon–Halogen Bond-Selective Boryl Substitution of Alkyl Halides Bearing Terminal Alkene Moieties

Iwamoto, H.; Kubota, K.; Yamamoto, E; Ito, H. Chem. Comm. 2015, 51, 9655–9658.
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Reaction Mechanism of the Anomalous Formal Nucleophilic Borylation of Organic Halides with Silylborane: Combined Theoretical and Experimental Studies

Uematsu, R.; Yamamoto, E.; Maeda, S.; Ito, H.; Taketsugu, T. J. Am. Chem. Soc. 2015, 137, 4090–4099.
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Boryl Substitution of Functionalized Aryl-, Heteroaryl- and Alkenyl Halides with Silylborane and an Alkoxy Base: Expanded Scope and Mechanistic Studies

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Interconvertible Multiple Photoluminescence Color of a Gold(I) Isocyanide Complex in the Solid State: Solvent-Induced Blue-Shifted and Mechano-Responsive Red-Shifted Photoluminescence

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Silicon-Tethered Strategy for Copper(I)-Catalyzed Stereo- and Regioselective Alkylboration of Alkynes

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Copper(I)-Catalyzed Enantioselective Nucleophilic Borylation of Aldehydes: An Efficient Route to Enantiomerically Enriched α-Alkoxyorganoboronate Esters

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Photoinduced Single-Crystal-to-Single-Crystal Phase Transition and Photosalient Effect of a Gold(I) Isocyanide Complex with Shortening Intermolecular Aurophilic Bonds

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A peptide ligase and the ribosome cooperate to synthesize the peptide ​pheganomycin.

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Enhancement of Optical Faraday Effect of Nonanuclear Tb(III) Complexes

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Copper(I)-Catalyzed Enantioselective Synthesis of α-Chiral Linear or Carbocyclic (E)-γ-Alkoxyallylboronates

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Design amphiphilic dipolar π-systems for stimuli-responsive luminescent materials using metastable states

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Selective Synthesis of Organoboron Compounds with Copper(I)-Phosphine Complex Catalysts

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Iridium-catalyzed ortho-C- borylation of aromatic aldimines derived from pentafluoroaniline with bis(pinacolate)diboron

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Cholesterol-Aided Construction of Distinct Self-Organized Materials from Luminescent Gold(I)-Isocyanide Complex Exhibiting Mechanochromic Luminescence

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Regio- and Enantioselective Monoborylation of Alkenylsilanes Catalyzed by an Electron-Donating Chiral Phosphine-opper(I) Complex

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Aromatic C- silylation of arenes with 1-hydrosilatrane catalyzed by an iridium(I)/2,9-dimethylphenanthroline (dmphen) complex

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Luminescence Color-Tuning through Polymorph Doping: Preparation of a White-Emitting Solid from a Single Gold(I)-socyanide Complex by Simple Precipitation

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Controlling Mechano- and Seeding-Triggered Single-Crystal-to-Single-Crystal Phase Transition: Molecular Domino with a Disconnection of Aurophilic Bonds

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Effect of Ligand Polarization on Asymmetric Structural Formation for Strongly Luminescent Lanthanide Complexes

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Iridium(I)-catalyzed vinylic C-H borylation of 1-cycloalkenecarboxylates with bis(pinacolato)diboron

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Mechanical stimulation and solid seeding trigger single-crystal-to-single-crystal molecular domino transformations

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Copper(I)-Catalyzed Borylative Exo-Cyclization of Alkenyl Halides Containing Unactivated Double Bond

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Anomalous Reactivity of Silylborane: Transition-Metal-Free Boryl Substitution of Aryl, Alkenyl, and Alkyl Halides with Silylborane/Alkoxy Base Systems

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Potassium tert-butoxide-mediated regioselective silaboration of aromatic alkenes

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Practical procedure for copper(I)-catalyzed allylic boryl substitution with stoichiometric alkoxide base

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Copper(I)-Catalyzed Boryl Substitution of Unactivated Alkyl Halides

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Copper(I)-Catalyzed Allylic Substitution of Silyl Nucleophiles through Si-Si Bond Activation

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Mechanistic Insight into the Anomalous syn-Selectivity Observed during the Addition of Allenylboronates to Aromatic Aldehydes

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Enantioselective Synthesis of trans-Aryl- and -Heteroaryl-Substituted Cyclopropylboronates by Copper(I)-Catalyzed Reactions of Allylic Phosphates with a Diboron Derivative

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Copper(I)-Catalyzed Asymmetric Monoborylation of 1,3-Dienes: Synthesis of Enantioenriched Cyclic Homoallyl- and Allylboronates

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Stereospecific Synthesis of Cyclobutylboronates through Copper(I)-Catalyzed Reaction of Homoallylic Sulfonates and a Diboron Derivative

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Desymmetrization of meso-2-Alkene-1,4-diol Derivatives through Copper(I)-Catalyzed Asymmetric Boryl Substitution and Stereoselective Allylation of Aldehydes

Ito, H.; Okura, T.; Matsuura, K.; Sawamura, M. Angew. Chem., Int. Ed. 2010, 122, 570–573.
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Direct Enantio-Convergent Transformation of Racemic Ssubstrates without Racemization or Symmetrization

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The Synthesis of Allenes by Cu(I)-Catalyzed Regio- and Stereoselective Reduction of Propargylic Carbonates with Hydrosilanes

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Gold(I) Hydride Intermediate in Catalysis: Dehydrogenative Alcohol Silylation Catalyzed by Gold(I) Complex

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Copper(I)-Catalyzed Substitution of Propargylic Carbonates with Diboron: Selective Synthesis of Multisubstituted Allenylboronates

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Reversible Mechanochromic Luminescence of [(C₆F₅Au)₂(μ-1,4-)]diisocyanobenzene

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Synthesis of Optically Active Boron-Silicon Bifunctional Cyclopropane Derivatives through Enantioselective Copper(I)-Catalyzed Reaction of Allylic Carbonates with a Diboron Derivative

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Synthesis and Sructural Characterization of a Tetranuclear Platinum(II) Metallamacrocycle Containing 1,3-Diisocyanoarene Ligands

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Design and Synthesis of Isocyanide Ligands for Catalysis: Application to Rh-Catalyzed Hydrosilylation of Ketones

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Electronically Tunable Compact Trialkylphosphines: SMAPs-bridged Bicyclic Phosphines

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Versatile Dehydrogenative Alcohol Silylation Catalyzed by Cu(I)-phosphine Complex

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Gold(I)-phosphine Catalyst for the Highly Chemoselective Dehydrogenative Silylation of Alcohols

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Nonvolatile Me₃P-like P-Donor Ligand: Synthesis and Properties of 4-Phenyl-1-phospha-4-silabicyclo-[2.2.2]-octane

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New Reactivity of a Reducing Reagent Generated from a Copper(I) Salt and a Hydrosilane: Selective Reduction of Ketones and Olefins Conjugated with an Aromatic Group

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First Gold Complex-catalysed Selective Hydrosilylation of Organic Compounds

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An Unprecedented Catalytic Reaction Using Gold(I) Complexes

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Highly Stereoselective Metathesis Reaction between Optically Active Hydrosilane and Copper(I) Salt in 1,3-Dimethyl-2-imidazolidinone

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Palladium-catalyzed Coupling Reactions of N-Methoxy-N-methylcarbamoyl Chloride for the Synthesis of N-Methoxy-N-methylamides

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Uncatalyzed Aldol Reaction Using a Dimethylsilyl Enolate and α-Dimethylsilyl Ester in N,N-Dimethylformamide

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Intramolecular Hydrogen Bond-promoted C-C Bond Formation: Reaction Rate Enhancement and Regioselective Allylation of Carbonyl Compounds

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New Method for Introduction of a Silyl Group into α,β-Enones using a Disilane Catalyzed by a Copper(I) Salt

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Selective O-Acylation of Silyl Enol Ethers with Acid Halides Mediated by a Copper(I) Salt

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Di-functionalization of Alkenes Using an Oxidant Generated from Manganese(II) Chloride under Oxygen: Synthesis of γ-Lactones

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Highly Stereoselective Intramolecular Addition of a Hydroxyl Group to Vinylsilanes via 1,2-Silyl Migration

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New Access to Cross-coupling Reaction between Arylsilanes or Heteroarylsilanes and Aryl Halides Mediated by a Copper(I) Salt

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Direct Alkynyl Group Transfer from Silicon to Copper: New Preparation Method of Alkynylcopper (I) Reagents

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A New Type of Allyl- and Prop-2-ynyl-manganese Species: Generation and Reactions with Electrophiles

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Preparation of (Alkaneimidoyl)lanthanides and Their Reactions with Carbonyl Compounds

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Alkyllithium-mediated Anomalous Trimerization of 2,6-Xylyl Isocyanide

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Regio- and Stereoselective Incorporation of a C-13 nuclide into D-ribo-Phytosphingosine via SmI2-mediated C-C Formation with C-13-Labeled Isocyanide

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Allylstannylation of Alkenes via Radical Process

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Allylstannylation of Alkynes via a Radical Process: Stereoselective Synthesis of Di- and Tri-substituted Vinylstannanes

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Titanocene- and Zirconocene-mediated Cyclization of Allyl Propargyl Ethers. Stereoselective Synthesis of 3-Methylenetetrahydrofurans

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”Tailor-made” Carbonyl Ylides: [3+2] Cycloaddition of the Parent and Optionally Substituted Nonstabilized Carbonyl Ylides

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Synthesis of Unsymmetrical α-Diketones via Autooxidation of α-Hydroxy Imines

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Stereoselective Synthesis of 2-Amino Alcohols by Use of an Isocyanide as an Aminomethylene Equivalent

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